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Xalkori

Latest Headlines

Latest Headlines

Pfizer's targeted Xalkori outshines chemo in trial of untreated lung cancer patients

Pfizer said its targeted cancer drug Xalkori trounced chemotherapy in a trial of previously untreated patients with a particular type of lung cancer. The study showed for the first time that up-front treatment with Xalkori staves off cancer growth better than other treatments in patients whose tumors test positive for ALK-gene abnormalities.

Cost gatekeepers give final 'no' to Pfizer's targeted cancer drug Xalkori

Clinically effective but not cost-effective. That's what U.K. watchdogs have determined about Pfizer's targeted lung cancer drug, Xalkori. Despite a discount offer from Pfizer, the National Institute for Health and Care Excellence still believes Xalkori isn't a good value.

NICE denies Pfizer lung cancer drug in final draft guidance

In the past, the U.K.'s cost-effectiveness gatekeeper has shown that it will bend preliminary draft guidance decisions if the price is right. But for Pfizer, which slashed costs on its targeted lung cancer drug Xalkori in hopes of gaining recommendation for its use in Britain's National Health Service, that price wasn't low enough.

European regulators tag 100-plus drugs with 'black triangle'

The labeling logo is designed to encourage doctors and patients to report side effects, as part of a new effort to more closely monitor drug safety. The list of 100-plus products includes all new drugs and biologics approved since January 2011.

German cost agency spurns Xalkori, Komboglyze

The well-armed German pricing gatekeepers have dismissed two more Big Pharma drugs. Pfizer's ($PFE) lung cancer treatment Xalkori and the Bristol-Myers Squibb ($BMY)/AstraZeneca ($AZN) diabetes drug Komboglyze both got an initial thumbs-down from the Institute for Quality and Efficiency in Health Care (IQWiG).

Pfizer's Xalkori, others spotlight spoils of computer-aided drug discovery

Computer-designed drugs have come of age. More than two decades after industry pioneer Joshua Boger set sail from Merck to start Vertex Pharmaceuticals ($VRTX) to advance structure-based drug design, the industry has seen multiple drugs discovered with the help of computers reach the finish line with FDA approvals.

Cheap Dx spots lung cancer mutation ripe for Pfizer drug

Personalized medicine takes another step forward, as scientists from Pfizer and South Korea make progress developing a diagnostic test that can quickly and cheaply identify patients who can benefit from the company's lung cancer drug Xalkori (crizotinib).

Pfizer sharpens job-cutting ax for U.S. sales layoffs

Pfizer's U.S. sales reps are updating their résumés. The company's primary care sales force faces another round of job cuts, numbers as yet unspecified. The laid-off reps--to be notified Dec. 20, Dow Jones reports--will join thousands of previous patent-cliff casualties.

Pfizer's Xalkori, Roche's TDM-1 among winners at ESMO

With the European Society of Medical Oncology meeting in Vienna, the cancer-drug studies are dropping like autumn leaves. But that's not all the cancer news today. As if to piggyback on the ESMO headlines, insurers and regulators have chipped in with their own oncology developments

Ariad grabs spotlight at ESMO with 'compelling' results for lung cancer drug

With its lead drug ponatinib on track to a likely approval in the U.S. and Europe, Ariad Pharmaceuticals ($ARIA) moved center stage at ESMO 2012 over the weekend with an early-stage cancer drug that produced some impressive results among a small population of non-small cell lung cancer patients.